Association between Preoperational Blood Profiles and Post Operational Complications in Patients Suffering Epithelial Ovarian Cancer

Leukocytosis is a para neo plastic syndrome which arises nearly in 30% of solid tumor. Anemia, leukocytosis, thrombocytosis and other para neo plastic disorders have been seen with numerous malignancies especially in advanced stages [1]. Para neo plastic syndrome often is seen with gynecologic, lung, breast and hematologic malignancies. Recent studies on leukocytosis and other blood markers in disease’s progression have shown the negative effect of leukocytosis on malignancies [2]. Ovarian cancer is one of the main reasons of gynecologic cancer related death. All over the world about 238700 new cases and 151900 deaths in 2013 was diagnosed [3]. Most cases are discovered in advanced stages. This problem is related to the nature of cancer and lack of sufficient screening program. Even when the patient with advanced disease who treated by cytoreductive surgery fallowed by adjuvant chemotherapy prognosis would be poor yet. So that 5 years survival is just 50% [3]. The known risk factors for unfavorable results are included: high age, high stage and grade, clear cell histology, excessive volume of ascites, the large volume of residual tumor in the first laparotomy [3]. Recently molecular biomarkers have being increasingly studied in order to diagnosis and define of primary prognosis. The relationship between mononucleotide polymorphism in some of cancer related gens and survival of patients are also response to chemotherapy in ovarian cancer has been discovered. At this matter can be pointed out to mononucleotide poly morphism in IGF 2 can lead to exceed the recurrence and death [4]. To study of the clinical outcomes of cancer stem cells and their superficial cell markers, there are some controversial about application of cell markers in ovarian cancer [5]. Also many of the mentioned studies which have been carried out with micro assay methods lead to high pseudo positive results in addition these studies are very different that may be because of the difference in micro assay techniques or analysis methodology [6].